pentobarbital will lessen the level or influence of diclofenac by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unknown.

pentobarbital will minimize the level or influence of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will minimize the level or effect of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

Check Closely (one)pentobarbital will lower the level or outcome of benzhydrocodone/acetaminophen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Warning when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may possibly improve and can result in likely deadly respiratory depression.

Contraindicated. Coadministration of doravirine with a robust CYP3A inducer may possibly decrease doravirine plasma concentrations and/or effects. Possible for loss of virologic reaction and doable resistance to doravirine.

Exercise caution when administered to sufferers with acute or Long-term pain; could lead to paradoxical enjoyment or significant symptoms could possibly be masked

pentobarbital will lessen the extent or effect of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Avoid coadministration of lefamulin with powerful or reasonable CYP3A inducers Except if the gain outweighs threats. Keep track of for lowered efficacy.

pentobarbital will minimize the extent or influence of colchicine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

pentobarbital will minimize the level or result of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will minimize the level or result of fentanyl transdermal by influencing hepatic/intestinal 戊巴比妥鈉製作 enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, not enough efficacy or, probably, growth of the withdrawal syndrome inside of a affected person who's got made physical dependence to fentanyl.

Contraindicated (one)pentobarbital will minimize the extent or outcome of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with potent CYP3A4 inducers is not really proposed

pentobarbital will decrease the extent or impact of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will reduce the extent or outcome of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Powerful or reasonable CYP3A4 inducers significantly minimize guanfacine plasma concentrations and elimination 50 percent-life.

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